Pathogenesis and treatment of oral candidosis.
Pathogenesis and treatment of oral candidosis.
复制标题
口服念珠菌病的发病机理和治疗。
DOI：
10.3402/jom.v3i0.5771
复制
发表时间：
2011-01-28
影响因子：
4.5
通讯作者：
Lewis M
中科院分区：
文献类型：
--
作者：
Williams D;Lewis M
由念珠菌属的酵母菌引起的口腔感染，特别是白色念珠菌（口腔念珠菌），在整个历史记录中已被认识到。然而，自20世纪80年代以来，对这些感染的兴趣和相关研究明显激增。这主要是由于在此期间口腔念珠菌病的发病率增加，主要是因为艾滋病毒感染和艾滋病流行的升级。此外，医疗实践的变化导致更多地使用侵入性临床程序和更广泛地使用免疫抑制疗法也导致了这个问题。虽然口腔念珠菌病以前被认为是一种疾病，主要是老年人和非常年轻的，它的发生在整个一般人群现在被承认。念珠菌是真正的“机会致病菌”，只有在宿主存在潜在的易感条件时才会引发口腔感染。由于传统抗真菌剂对宿主细胞的潜在毒性，这些感染的治疗一直存在问题。除了C.对传统抗真菌药物具有内在抗性的白色念珠菌。本综述的目的是给读者一个当代概述口腔念珠菌病，所涉及的生物体，以及管理策略，目前采用或可以在未来使用。
Oral infections caused by yeast of the genus Candida and particularly Candida albicans (oral candidoses) have been recognised throughout recorded history. However, since the 1980s a clear surge of interest and associated research into these infections have occurred. This has largely been due to an increased incidence of oral candidosis over this period, primarily because of the escalation in HIV-infection and the AIDS epidemic. In addition, changes in medical practice leading to a greater use of invasive clinical procedures and a more widespread use of immunosuppressive therapies have also contributed to the problem. Whilst oral candidosis has previously been considered to be a disease mainly of the elderly and very young, its occurrence throughout the general population is now recognised. Candida are true ‘opportunistic pathogens’ and only instigate oral infection when there is an underlying predisposing condition in the host. Treatment of these infections has continued (and in some regards continues) to be problematic because of the potential toxicity of traditional antifungal agents against host cells. The problem has been compounded by the emergence of Candida species other than C. albicans that have inherent resistance against traditional antifungals. The aim of this review is to give the reader a contemporary overview of oral candidosis, the organisms involved, and the management strategies that are currently employed or could be utilised in the future.