International variation in the incidence of adult primary malignant neoplasms of the brain and central nervous system
International variation in the incidence of adult primary malignant neoplasms of the brain and central nervous system
复制标题
DOI：
10.1007/s10552-009-9404-1
复制
发表时间：
2009-11-01
影响因子：
2.3
通讯作者：
Dubrow, Robert
中科院分区：
文献类型：
--
作者：
Darefsky, Amy S.;Dubrow, Robert
我们研究了69个人群中成人脑癌发病率的国际差异，这些人群来自符合严格质量标准的五大洲癌症发病率第IX卷中的癌症登记处子集。我们将这些人口分为世界地区。不同地区的标准化发病率在男性和女性中的差异相似，北方美洲非西班牙裔白人和澳大利亚人最高，其次是欧洲人，然后是南美人和北方美洲西班牙裔白人。中南亚洲人和北方美国黑人的患病率是北方美国非西班牙裔白人的一半到五分之三。东亚人、东南亚人、北方美洲人和太平洋岛民的患病率是北方美洲非西班牙裔白人的三分之一到五分之二。前两个人群的发病率随年龄增长的增加幅度小于其他人群。这些结果有力地表明，东亚和东南亚的人口，无论居住地，有显着较低的脑癌发病率比白色人口，由于遗传易感性和/或环境/生活方式的差异，持续在移民人群中的暴露。男性/女性发病率比率随年龄而变化，但不随世界地区而变化，表明这种男性/女性差异是基于生物学的。
We examined international variation in adult brain cancer incidence in 69 populations from a subset of cancer registries included in Cancer Incidence in Five Continents, Volume IX that met stringent quality standards. We grouped these populations into World Areas. Age-standardized incidence rates varied by World Area similarly for men and women and were highest in northern America non-Hispanic whites and Australians, followed closely behind by Europeans, then South Americans and northern America Hispanic whites. Rates among south-central Asians and northern America blacks were half to three-fifths the rates among northern America non-Hispanic whites. Rates among eastern and southeastern Asians and northern America Asians and Pacific Islanders were one-third to two-fifths the rates among northern America non-Hispanic whites. Incidence rates increased less steeply with age in the former two populations than in other populations. These results strongly suggest that populations of eastern and southeastern Asian origin, regardless of residence, have substantially lower brain cancer incidence rates than white populations, due to differences in genetic susceptibility and/or environmental/lifestyle exposures that persist in migrant populations. Male/female incidence rate ratios varied by age, but not by World Area, suggesting that this male/female difference is biologically based.