Elastography for the follow-up of high-intensity focused ultrasound prostate cancer treatment:: Initial comparison with MRI
Elastography for the follow-up of high-intensity focused ultrasound prostate cancer treatment:: Initial comparison with MRI
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DOI：
10.1016/j.ultrasmedbio.2005.06.013
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发表时间：
2005-11-01
影响因子：
2.9
通讯作者：
Chapelon, JY
中科院分区：
文献类型：
--
作者：
Curiel, L;Souchon, R;Chapelon, JY
我们以前开发了一种超声弹性成像系统，可以提供一种简单且具有成本效益的解决方案来监测高强度聚焦超声（HIFU）治疗。本临床研究的目的是通过与磁共振成像（MRI）进行比较，评估我们的系统在评估前列腺HIFU病变体积方面的可靠性。在20例前列腺癌患者接受HIFU治疗后获得弹性图，并进行钆增强T1和T2加权MRI。手动勾画病变边界并计算体积。发现病变体积的弹性成像和MRI测量之间存在统计学显著相关性p = 0.62（p = 0.022），弹性成像测量通常低估了MRI中测量的体积。一些基本的物理学（低回声区）和仪器（帧速率和带宽）的问题，是有害的图像质量在体内的报告，沿着的建议，以改善技术。由于这些问题，尽管在一些患者中发现弹性成像和MRI测量结果之间具有良好的对应性，但弹性成像测量结果无法预测单个个体的MRI测量结果。然而，结果证实了弹性成像监测前列腺HIFU治疗的潜力。将使用更合适的超声设备进行进一步研究，并进行实时弹性成像计算。（电子邮件：chapelon@lyon.inserm.fr）（C）2005年世界医学和生物学超声联合会。
We previously developed an ultrasonic elastography imaging system that may provide a simple and cost-effective solution to monitor high-intensity focused ultrasound (HIFU) treatments. The objective of this clinical study was to evaluate the reliability of our system in assessing the volume of HIFU lesions in the prostate, using a comparison with magnetic resonance imaging (MRI). Elastograms were obtained in 20 patients after HIFU treatment for prostate cancer and gadolinium-enhanced T1- and T2-weighted MRI was performed. Lesion boundaries were manually outlined and the volume was calculated. A statistically significant correlation of p = 0.62 (p = 0.022) was found between elastographic and MRI measurements of lesion volume, with elastographic measurements that generally underestimated the volume measured in MRI. Some basic physics (hypoechoic areas) and instrumentation (frame rate and band width) issues that were detrimental to image quality in vivo are reported, along with propositions to improve the technique. Because of these issues and, although good correspondence between elastographic and MRI measurements was found in some patients, elastographic measurements were unable to predict MRI measurements in a single individual. Nevertheless, the results confirmed the potential of elastography for monitoring HIFU treatment of the prostate. Further investigation will be conducted using better suited ultrasound equipment and performing real-time elastogram calculations. (E-mail: chapelon@lyon.inserm.fr) (C) 2005 World Federation for Ultrasound in Medicine & Biology.