Glutathione levels and immune responses in tuberculosis patients
Glutathione levels and immune responses in tuberculosis patients
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DOI：
10.1016/j.micpath.2007.09.002
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发表时间：
2008-03-01
影响因子：
3.8
通讯作者：
Connell, Nancy D.
中科院分区：
文献类型：
--
作者：
Venketaraman, Vishwanath;Millman, Ariel;Connell, Nancy D.
从结核病患者分离的外周血单核细胞和红细胞中的谷氨酰胺水平显著降低。用谷胱甘肽前体N-乙酰半胱氨酸治疗结核病患者的血培养，与细胞内结核分枝杆菌感染的控制改善相关。N-乙酰半胱氨酸治疗降低了结核病患者血培养物中IL-10、IL-6、TNF-α和IL-1的水平，有利于宿主免疫细胞成功地控制M.结核复制(C)2007爱思唯尔有限公司保留所有权利。
Glutathione levels are significantly reduced in peripheral blood mononuclear cells and red blood cells isolated from tuberculosis patients. Treatment of blood cultures from tuberculosis patients with N-acetyl cysteine, a glutathione precursor, was associated with improved control of intracellular M tuberculosis infection. N-acetyl-cysteine treatment decreased the levels of IL-10, IL-6, TNF-alpha and IL-1, in blood Cultures derived from tuberculosis patients, favoring the host immune cells to successfully control M. tuberculosis replication. (C) 2007 Elsevier Ltd. All rights reserved.