A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy
A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy
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DOI：
10.1056/nejmoa1808779
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发表时间：
2019-02-14
影响因子：
158.5
通讯作者：
McRobbie, Hayden J.
中科院分区：
文献类型：
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作者：
Hajek, Peter;Phillips-Waller, Anna;McRobbie, Hayden J.
香烟是常用的尝试戒烟，但证据是有限的，关于他们的有效性相比，尼古丁产品批准为戒烟treatment. METHODS我们随机分配成人参加英国。国民健康服务停止吸烟服务，他们选择的尼古丁替代产品，包括产品组合，提供长达3个月，或电子烟启动包（第二代可再填充电子烟，含一瓶尼古丁电子液体[每毫升18毫克]），并建议购买他们选择的口味和强度的其他电子液体。治疗包括每周一次的行为支持，持续至少4周。主要结果是持续禁欲1年，这在最后一次访视时进行了生物化学验证。失访或未提供生化验证的参与者被视为未禁欲。次要结果包括参与者报告的治疗使用情况和呼吸道症状。电子烟组的1年戒烟率为18.0%，而尼古丁替代组为9.9%（相对风险为1.83; 95%置信区间[CI]为1.30至2.58; P
BACKGROUNDE-cigarettes are commonly used in attempts to stop smoking, but evidence is limited regarding their effectiveness as compared with that of nicotine products approved as smoking-cessation treatments.METHODSWe randomly assigned adults attending U.K. National Health Service stop-smoking services to either nicotine-replacement products of their choice, including product combinations, provided for up to 3 months, or an e-cigarette starter pack (a second-generation refillable e-cigarette with one bottle of nicotine e-liquid [18 mg per milli-liter]), with a recommendation to purchase further e-liquids of the flavor and strength of their choice. Treatment included weekly behavioral support for at least 4 weeks. The primary outcome was sustained abstinence for 1 year, which was validated biochemically at the final visit. Participants who were lost to follow-up or did not provide biochemical validation were considered to not be abstinent. Secondary outcomes included participant-reported treatment usage and respiratory symptoms.RESULTSA total of 886 participants underwent randomization. The 1-year abstinence rate was 18.0% in the e-cigarette group, as compared with 9.9% in the nicotine-replacement group (relative risk, 1.83; 95% confidence interval [CI], 1.30 to 2.58; P