Detection of latent tuberculosis by the tuberculin skin test and a whole-blood interferon-γ release assay, and the development of active tuberculosis in HIV-seropositive persons
Detection of latent tuberculosis by the tuberculin skin test and a whole-blood interferon-γ release assay, and the development of active tuberculosis in HIV-seropositive persons
复制标题
DOI：
10.1016/j.diagmicrobio.2010.09.005
复制
发表时间：
2011-01-01
影响因子：
2.9
通讯作者：
Podzamczer, Daniel
中科院分区：
文献类型：
--
作者：
Santin, Miguel;Casas, Susana;Podzamczer, Daniel
本研究评估了QuantiFERON-TB金管（QFT-GIT; Cellestis, Carnegie, Australia）试验和结核菌素皮肤试验（TST）对hiv感染成人潜伏性结核感染（LTBI）的检测效果。135名hiv血清阳性者和135名对照者接受了TST和QFT-GIT检测。对任何一项检测结果呈阳性的艾滋病毒感染患者提供化学预防。hiv血清阳性受试者中，TST组LTBI患病率为6.7%，QFT-GIT组为9.6% (P = 0.3)，对照组中TST组为34.8%，QFT-GIT组为21.5% （P = 0.02）。TST反应性急剧下降，CD4（+）细胞在bbb500,301 -500和500,301 -500和bbb500,301 -500中分别下降15.8%，10.3%和0%
This study evaluated the QuantiFERON-TB Gold In-Tube (QFT-GIT; Cellestis, Carnegie, Australia) test and the tuberculin skin test (TST) for the detection of latent tuberculosis infection (LTBI) in HIV-infected adults. One hundred thirty-five HIV-seropositive persons and 135 controls underwent TST and QFT-GIT. HIV-infected patients who gave a positive result on either test were offered chemoprophylaxis. The prevalence of LTBI was 6.7% by TST and 9.6% by QFT-GIT (P = 0.3) in HIV-seropositive subjects, and 34.8% by TST and 21.5% by QFT-GIT (P = 0.02) among controls. TST reactivity declined sharply as CD4(+) cells fell (15.8%, 10.3%, and 0% for >500, 301-500 and 500, 301-500, and