Hippocampal Functioning and Verbal Associative Memory in Adolescents with Congenital Hypothyroidism.
Hippocampal Functioning and Verbal Associative Memory in Adolescents with Congenital Hypothyroidism.
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DOI：
10.3389/fendo.2015.00163
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发表时间：
2015
影响因子：
5.2
通讯作者：
Rovet JF
中科院分区：
文献类型：
--
作者：
Wheeler SM;McLelland VC;Sheard E;McAndrews MP;Rovet JF
甲状腺激素（TH）对海马体的正常发育至关重要，海马体对记忆至关重要，尤其是对学习和回忆视觉和语言刺激之间的联系。患有先天性甲状腺功能减退症（CH）的青少年，在妊娠晚期和生命早期缺乏甲状腺激素，表现出较弱的言语回忆能力，海马体积减少，海马对视觉相关材料的功能异常。然而，尚不清楚他们的海马体是否在记忆语言联想时功能异常。我们的目的是利用功能磁共振成像（fMRI）评估CH患者的海马功能。研究了14名青少年CH和14名典型发育对照（TDC）。参与者研究了成对的单词，然后，在fMRI获取过程中，做出两种类型的识别决定：一种是判断这些单词对是否与最初看到的相同，另一种是判断单个单词在之前是否见过，而不考虑配对。海马的激活对比项目两组更大，但这种差异仅在TDC显著。当我们直接比较两组时，右海马前部是TDC组和CH组在配对记忆效应上存在差异的主要区域。结果表明，青少年CH在言语记忆加工过程中表现出异常的海马功能。
Thyroid hormone (TH) is essential for normal development of the hippocampus, which is critical for memory and particularly for learning and recalling associations between visual and verbal stimuli. Adolescents with congenital hypothyroidism (CH), who lack TH in late gestation and early life, demonstrate weak verbal recall abilities, reduced hippocampal volumes, and abnormal hippocampal functioning for visually associated material. However, it is not known if their hippocampus functions abnormally when remembering verbal associations. Our objective was to assess hippocampal functioning in CH using functional magnetic resonance imaging (fMRI). Fourteen adolescents with CH and 14 typically developing controls (TDC) were studied. Participants studied pairs of words and then, during fMRI acquisition, made two types of recognition decisions: in one they judged whether the pairs were the same as when seen originally and in the other, whether individual words were seen before regardless of pairing. Hippocampal activation was greater for pairs than items in both groups, but this difference was only significant in TDC. When we directly compared the groups, the right anterior hippocampus was the primary region in which the TDC and CH groups differed for this pair memory effect. Results signify that adolescents with CH show abnormal hippocampal functioning during verbal memory processing.