Estrogen Biosynthesis in Leiomyoma and Myometrium of the Uterus
Estrogen Biosynthesis in Leiomyoma and Myometrium of the Uterus
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子宫平滑肌瘤和子宫肌层中的雌激素生物合成
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
H. Okada
中科院分区：
文献类型：
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作者：
T. Yamamoto;K. Takamori;H. Okada
子宫肌瘤在临床上很常见。其发病率在子宫良性肿瘤中最高。已知该肿瘤的隔室由肌纤维和结缔组织组成。子宫肌瘤的生长与雌激素密切相关（John 和 Martin 1971；Wilson、Yang 和 Rees 1980；Buttram 和 Reiter 1981）。此外，平滑肌瘤主要在绝经前发生，绝经后其尺寸减小。许多研究者已经报道了与子宫肌瘤和子宫肌层中类固醇激素受体相关的基础研究，但其发育和生长的真正起源仍然未知。
Uterine leiomyoma is observed frequently in the clinic. Its incidence is highest among benign Uterine tumors. The compartments of this tumor are known to consist of muscular fibers and connective tissue. The growth of uterine leiomyoma is closely associated with estrogen (John and Martin 1971; Wilson, Yang and Rees l980; Buttram and Reiter 1981). In addition, leiomyoma develops principally in the premenopausal period and its size decreases after menopause. Basic research related to steroid hormone receptors in the leiomyoma and myometrium of the uterus has been reported by many investigators, but the true origin of its development and growth remains unknown.