Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings
Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings
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DOI：
10.1097/00002030-200401001-00005
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发表时间：
2004-01-01
期刊：
影响因子：
3.8
通讯作者：
Heaton, RK
中科院分区：
文献类型：
--
作者：
Cherner, M;Ellis, R;Heaton, RK
目的：衰老对HIV相关神经认知障碍的影响在很大程度上是未知的。在一项横断面观察性研究中，我们比较了67名年龄至少50岁的HIV阳性患者与52名年龄在35岁或以下的参与者的神经心理学特征。原始的神经心理测试分数被转换为人口统计学校正的T分数;所有这些都被校正了正常老化的影响。损害的临床评级被分配到neuropsychologicalresults.Results：两组没有统计学差异，人口统计学变量，艾滋病的百分比，或CD 4细胞计数。“年轻”组血浆和脑脊液（CSF）中的病毒负荷较高，接受抗逆转录病毒治疗的人数较少。“老年”组中神经心理受损受试者的比例略高于年轻组，老年组在大多数能力领域的受损率往往更高。当对CSF病毒载量的组间差异进行统计学建模时，病毒载量和年龄都是神经心理学损害的重要预测因子，病毒载量和年龄之间存在显著的相互作用。脑脊液中可检测到病毒的老年人神经心理障碍的患病率是检测不到病毒的老年人的两倍。在年轻人中，这一比例不受病毒载量的影响。终身重度抑郁症，物质使用障碍，目前的抑郁症状与neuropsychological impairment.Conclusion：虽然需要更大和更老的样本进一步研究，这项调查表明，老年人可能会在更大的风险艾滋病毒相关的神经认知功能障碍。(C)2004年利平科特威廉姆斯威尔金斯。
Objective: The effects of aging on the presentation of HIV-associated neurocognitive disorders are largely unknown. in a cross-sectional observational study, we compared the neuropsychological profiles of 67 HIV-positive patients aged at least 50 years with those of 52 participants aged 35 years or less.Methods: Participants received neuropsychological, psychiatric and neuromedical evaluations. Raw neuropsychological test scores were converted to demographically corrected T-scores; all were corrected for the effects of normal aging. Clinical ratings of impairment were assigned to the neuropsychological results.Results: The two groups did not differ statistically with respect to demographic variables, percentage with AIDS, or CD4 cell counts. The 'younger' group had higher viral burdens in plasma and cerebrospinal fluid (CSF), and fewer were receiving antiretroviral treatment. The proportion of neuropsychologically impaired subjects in the 'older' group was slightly greater than in the younger group, and the older group tended to have higher rates of impairment across most ability domains. When group differences in CSF viral load were modeled statistically, both viral burden and age were significant predictors of neuropsychological impairment, together with a significant interaction between viral burden and age. Older individuals with detectable virus in CSF had twice the prevalence of neuropsychological impairment of those with undetectable levels. Among younger individuals, this proportion was not affected by viral load. Lifetime major depression, substance use disorder, and current depression symptoms were not associated with neuropsychological impairment.Conclusion: Although further studies with larger and older samples are needed, this investigation suggests that older adults may be at greater risk of HIV-related neurocognitive dysfunction. (C) 2004 Lippincott Williams Wilkins.