A practical source of chlorodifluoromethyl radicals. Convergent routes to gem-difluoroalkenes and -dienes and (2,2-difluoroethyl)-indoles, -azaindoles, and -naphthols.
A practical source of chlorodifluoromethyl radicals. Convergent routes to gem-difluoroalkenes and -dienes and (2,2-difluoroethyl)-indoles, -azaindoles, and -naphthols.
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DOI：
10.1021/ol501063a
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发表时间：
2014-05
期刊：
影响因子：
5.2
通讯作者：
Pierre Salomon;S. Zard
中科院分区：
文献类型：
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作者：
Pierre Salomon;S. Zard
本文叙述了从一氯二氟乙酸制备O-十八烷基-S-氯二氟甲基黄原酸酯及其作为一种方便的氯二氟甲基自由基来源的用途。该试剂可用于获得偕-二氟烯烃和偕-二烯，以及（2，2-二氟乙基）吲哚啉、偕-吲哚和偕-萘酚。
The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.