Biochemistry of tropoelastin: functional analysis of an essential cell-interactive domain
Biochemistry of tropoelastin: functional analysis of an essential cell-interactive domain
批准号:
DP1096608
负责人:
Prof Anthony Weiss
金额:
$31.35万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-31 至 2013-01-29
中文摘要
弹性蛋白比最好的人造合成橡胶耐用十倍,因为我们的身体需要控制皮肤、动脉和肺部危及生命的撕裂。温血动物利用弹性蛋白在这些组织中为多种生物环境构建了具有弹性的弹性材料。在这个项目中,我们将了解更多关于弹性蛋白的最保存和功能部分。这些发现将增加我们对弹性蛋白质结构的宏伟建筑规则的理解。我们将学习在弹性环境中管理细胞相互作用的新方法,并定义设计规则,以帮助未来设计新的细胞结合,弹性复合材料。
英文摘要
Elastin is ten times more durable than the best man-made synthetic rubbers because our bodies need to control life-threatening rips in skin, artery and lung. Warm-blooded animals use elastin to build diversely shaped elastic materials for multiple biological environments in these tissues. In this project, we will learn a lot more about the most preserved and functional part of elastin. These discoveries will increase our understanding of the grand architectural rules by which elastic protein-based structures are made. We will learn new ways to manage cell interactions in an elastic environment and define design rules to assist in the future design of new cell-binding, elastic, composite materials.
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会议论文
Versatile elastin based hybrid hydrogels for chondrocyte transplantation and repair
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批准号:DP120103911
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项目类别:Discovery Projects
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资助金额:$20.06万
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财政年份:2012
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负责人:Prof Anthony Weiss
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依托单位:
Elastaderm: an improved human skin substitute for treating burns
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批准号:nhmrc : 1000507
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项目类别:NHMRC Development Grants
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资助金额:$21.76万
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财政年份:2010
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负责人:Prof Anthony Weiss
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依托单位:
Biochemistry of tropoelastin and elastin: the molecular architecture of elastic fibre assembly
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批准号:DP0774289
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项目类别:Discovery Projects
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资助金额:$20.47万
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财政年份:2007
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负责人:Prof Anthony Weiss
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依托单位:
Biomaterial applications of synthetic elastin
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批准号:LX0561916
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项目类别:Linkage - International
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资助金额:$1.67万
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财政年份:2005
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负责人:Prof Anthony Weiss
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依托单位:
Biochemistry of tropoelastin and elastin
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批准号:DP0344773
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项目类别:Discovery Projects
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资助金额:$20.94万
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财政年份:2003
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负责人:Prof Anthony Weiss
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依托单位:
国内基金
海外基金
基于P-SLex双靶向超声微泡在体探讨滋肾清肝方改善动脉细胞外基质Tropoelastin蓄积抗AS的机制研究
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批准号:81901756
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项目类别:青年科学基金项目
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资助金额:21.0万元
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批准年份:2019
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负责人:朱正球
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依托单位:
携载tropoelastin基因血管平滑肌细胞移植对腹主动脉瘤壁负载结构与功能再生的实验研究
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批准号:30672054
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项目类别:面上项目
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资助金额:27.0万元
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批准年份:2006
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负责人:王深明
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依托单位: