Topoisomerase II beta occupancy and ablation in human cancer cells
Topoisomerase II beta occupancy and ablation in human cancer cells
批准号:
364841
负责人:
Su Qiao
金额:
$0.36万
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2017-05-01
中文摘要
II型拓扑异构酶(TOP 2)是催化基因组中双链断裂(DSB)的形成和重新连接的酶。TOP2毒物通过对癌细胞造成DNA损伤来治疗许多类型的癌症。然而,这些毒药干扰
英文摘要
Type II topoisomerases (TOP2) are enzymes that catalyze the formation and rejoining of double stranded breaks (DSB) in the genome. TOP2 poisons are used to treat many types of cancer by causing DNA damage to cancerous cells. However, these poisons interfe
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