Analyses of the molecular roles of Tubby, the founding member of the developmentally important TUB Domain protein family

在小鼠和人类中，Tubby （Tub）基因的突变会导致成熟型肥胖、胰岛素抵抗和视网膜色素变性。Tub和相关的Tub样蛋白Tulp1、2、3和4都含有一个新的核酸结合结构域——Tub结构域。无足轻重的人

In mice and humans, mutations in the Tubby (Tub) gene cause maturity-onset obesity, insulin resistance, and retinitis pigmentosa. Tub and the related Tub-like proteins Tulp1, 2, 3 and 4 all contain a novel nucleic acid binding domain - the TUB domain. Mut