Delineating the functional role of the amyloid precursor protein's copper binding domain

这项研究将确定铜和淀粉样前体蛋白(APP)分子之间的相互作用如何调节铜的动态平衡和APP代谢。由于铜的动态平衡受到严格的调控，对正常的细胞功能至关重要，因此了解铜的动态平衡的调节对于基础生物学很重要。此外，APP直接参与导致阿尔茨海默氏症，因此了解APP和铜之间的相互作用通过对抗衰老和阿尔茨海默氏症对社区健康具有潜在的好处。

This study will define how the interaction between copper and the amyloid precursor protein (APP) molecule regulates copper homeostasis and APP metabolism. Since copper homeostasis is tightly regulated and vital for normal cellular function, understanding the regulation copper homeostasis is important for basic biology. Moreover, APP is directly involved in causing Alzheimer's disease and therefore understanding the interaction between APP and copper has potential benefits for community health by combating aging and Alzheimer's disease.