Modeling and Optimization of Fed-Batch Cultures

本研究的目的是发展选择性的 分批培养杆菌生产的操作政策 代谢产物 三种芽孢杆菌， 重要的酶产物将作为模型系统进行研究。 的 具体目标是为各种 诱导-抑制现象，以制定最佳经营政策 基于使用各种措施的轨迹优化技术 生物反应器的性能，并验证和实施最佳的 使用高度仪表化的计算机控制的操作策略 发酵罐

The objectives of this research focus on the development of optional operating policies for feeding batch cultures of bacilli to produce metabolic products. Three ;itBacillus;ro species which produce important enzyme products are to be studied as model systems. The specific goals are to develop modeling for a variety of induction-repression phenomena, to develop optimal operating policies based on trajectory optimization techniques using a variety of measures of bioreactor performance, and to verify and implement the optimal operating policies using a highly instrumented computer-controlled fermentor.