NOVEL MASS-SCALE BIOSYNTHESIS: TAILORING CHEMICAL LOGIC & BIOSYNTHESIS

在不久的将来，预计不会有新的抗革兰氏阴性“超级细菌”的抗生素问世。我们已经耗尽了天然产品池中的化学空间，对自然界中的抗生素缺乏基本的了解，这是针对细菌耐药性的抗生素设计的主要障碍。这项建议旨在设计独特的化学-酶平台来合成新的脂肽支架，这将显着扩大可用于新抗生素发现的化学空间。这些独特平台的开发将极大地扩大我们的天然产品抗生素库存，并将代表着澳大利亚生物技术和制药制造行业的重大技术突破。

No new antibiotics against Gram-negative ‘superbugs’ are expected to be available in the near future. We have exhausted the chemical space from the natural product pool and lack a fundamental understanding of antibiotics in nature, this is a major hurdle for antibiotic design targeting bacterial resistance. This proposal aims to engineer unique chemo-enzymatic platforms for the synthesis of new lipopeptide scaffolds which will significantly expand the chemical space available for novel antibiotic discovery. The development of these unique platforms will greatly expand our inventory of natural product antibiotics and will represent a major technological break-through for Australia's biotechnology and pharmaceutical manufacturing sectors.