Acquisition of a Photomicroscope

这一建议要求资金购买一个多功能的国家- 最先进的显微摄影装置，供12个 分子生物学系的研究人员。 的 部门是新的，但已经获得国际 在X射线晶体学领域的突出表现 光谱学、计算机图形学和有机化学。 的 光学显微镜对开展以下研究至关重要：差距 连接通讯，衣原体遗传学分析 运动性，调节透镜纤维连接的表达， 酵母细胞分裂的遗传分析，特异性基因 哺乳动物海马中的表达， 骨髓细胞和其他组织，salarylin的存活 巨噬细胞，锥虫的发育调节表达 cruizi表面蛋白，Serratia marescens中的颜色变化， 盘状网柄藻形态发生的遗传控制， 溶组织内阿米巴的分子生物学研究 肌肉m线中的细胞骨架蛋白，以及 荧光显微镜法测定荧光素选择性 放大 此外，显微镜将使 部门将其活动扩展到新的领域， 荧光信号，弱光增强或增强 程序和延时视频分析， 发展研究。

This proposal requests funds to purchase a versatile state-of- the-art photomicroscope unit for the communal use of twelve investigators in the Department of Molecular Biology. The Department is new but has already obtained international prominence in the areas of x-ray crystallography NMR spectroscopy, computer graphics, and organic chemistry. The photomicroscope is critical for the conduct of research on: gap junction communication, genetic analysis of chlamydomonas motility, regulation of expression of lens fibre junctions, genetic analysis of cell division in yeast, specific gene expression in mammalian hippocampus, expression of hemin p. 70 in bone marrow cells and other tissues, survival of salmonella in macrophages, developmentally regulated expression of trypanosoma cruizi surface proteins, color variation in serratia marescens, genetic control of morphogenesis in dictyostelium discoidium and molecular studies of entamoeba histolytica, characterization of a cytoskeletal protein in the m-line of muscle, and importance of fluorescence microscopy for antineoplastic selectivity amplification. Additionally the photomicroscope will enable the department to expand its activities into new areas such as fluorescence signals, low-light intensification or enhancement procedures, and time-lapse video analysis for embryonic development studies.