Physico-Chemical Studies on DNA-Protein Interactions

很明显，理解这一点的关键是 遗传信息传递的机理与控制 关于DNA与各种蛋白质的相互作用， 酶和非酶。 DNA的特异性表达 由蛋白质组成的结构参与了DNA的每一步 复制、转录和重组。 虽然 大量关于DNA-蛋白质相互作用的信息 在过去的几年里， 这些DNA结合的序列识别机制 蛋白质仍有待阐明。 吴博士将继续研究分子机制 DNA结合蛋白在基因表达中的作用 表情 具体重点将放在（1）两者 结构和动态方面的问题 通过RNA聚合酶和其他调节因子在天然DNA上的位点 蛋白质和（2）影响操作的因素， 基因表达的调控。

It has become apparant that the key to understanding the mechanism and control of genetic information transfer resides on the interactions of DNA with various proteins, both enzymatic and non-enzymatic. Specific recognitions of DNA structure by proteins are involved at every step of DNA replication, transcription and recombination. Although a tremendous amount of information on DNA-protein interactions has accumulated over the past several years, the molecular mechanisms of the sequence recognition by these DNA-binding proteins still remain to be elucidated. Dr. Wu will continue to investigate the molecular mechansims and functional roles of DNA binding proteins in gene expression. Specific emphasis will be placed on (1) both structural and dynamic aspects of the recognition of specific sites on native DNA by RNA polymerase and other regulatory proteins and (2) the factors that affect the operation and regulation of gene expression.