Theoretical and Experimental Research into Biological Mechanisms Underlying Learning and Memory

该提案要求资金支持研究，以找到能够解释细胞水平和各种更高水平的实验数据的组织原则。具体目标包括：阐明学习对突触修饰的依赖性，阐明控制突触形成或修饰的原理，构建突触修饰的分子模型，构建能够计算、学习、联想和重现抽象、语言习得和语音识别等更高层次认知行为的网络模型。通过检验批判性理论，首席研究员将试图更好地理解中枢神经系统学习和组织自身并获得精神行为能力的基本生物学机制。主要和主要研究人员资金充足，精通与所提出的研究相关的各种技术和理论框架。他们完全有资格进行这项研究。理论学家和实验学家的相互作用将使理论和实验相结合，这是本建议的主要优势。建议使用Support。

This proposal requests funds to support research to find principles of organization that can account for experimental data on the cellular level and on various higher levels. Specific objectives include: clarifying the dependence of learning on synaptic modification, elucidating the principles that govern synapse formation or modification, constructing a molecular model for synaptic modificaton, constructing network models that can compute, learn, associate, and reproduce such higher level cognitive acts as abstraction, language acquisition, and speech recognition. By testing critical theories, the principal investigator will attempt to obtain a better understanding of the basic biological mechanisms by which the cental nervous system learns and organizes itself and acquires its capacity for mental acts. The principal and coprincipal investigators are well funded and well versed in a wide variety of techniques and theoretical frameworks germane to the research proposed. They are well qualified to conduct the research. The interaction of theoreticians and experimentalists will allow the coupling of theory and experimentation, a major strength of this proposal. Support is recommended.