Defining the molecular basis for Salmonella persistence

动物和人类的沙门氏菌感染给农业食品和卫生保健部门带来了重大负担。所有哺乳动物和鸟类物种都可能慢性感染沙门氏菌，这种慢性携带是其他动物和人类疾病和暴发的宿主。我们对沙门氏菌感染的理解仍然存在重大差距，包括建立慢性携带者状态所涉及的分子机制。我们确定了几个沙门氏菌特异性基因，随后的小鼠研究表明，缺乏这些基因的沙门氏菌突变体在小鼠中，特别是在胆囊中被减弱。在这个项目中，我们试图了解衰减的分子基础和每种蛋白质对疾病的贡献

Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We identified several Salmonella specific genes and subsequent murine studies revealed that a Salmonella mutant lacking these genes is attenuated in mice and especially in the gallbladder. In this project we seek to understand the molecular basis for attenuation and the contribution of each protein to disease