Illuminating the structure and dynamics of the proteasomal Rpn1 protein in unfolded client recognition by methyl-TROSY NMR
Illuminating the structure and dynamics of the proteasomal Rpn1 protein in unfolded client recognition by methyl-TROSY NMR
批准号:
375860
负责人:
Harkness Robert
金额:
$9.83万
依托单位:
依托单位国家:
加拿大
项目类别:
Fellowship Programs
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-11-01 至 2020-11-01
中文摘要
人类的健康依赖于在不再需要旧蛋白质时适当降解它们的能力。蛋白质的降解是由一个叫做蛋白酶体的巨大的蛋白质机器来完成的。当蛋白质降解受损,神经退行性死亡
英文摘要
Human health relies on the ability to properly degrade old proteins when they are no longer needed. The degradation of proteins is carried out by an enormous protein machine called the proteasome. When protein degradation is impaired, neurodegenerative di
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