U.S.-Mexico Cooperative Research: Effects of Prostaglandin B1 Oligomers on Membrane Ca 2+-ATPase

该奖项将支持哈内曼大学医学院的Thomas Devlin教授和墨西哥城墨西哥国立自治大学（UNAM）的Salvador Uribe教授之间的合作研究。研究人员打算研究前列腺素聚合物对人红细胞质膜和兔心脏肌膜中钙atp酶的影响。他们还将研究PG聚合物对大鼠肝细胞代谢的影响。人类造血细胞酶的研究将在哈内曼大学进行，而兔心脏肌膜和肌肉肌浆网的研究将在墨西哥国立大学进行。调查人员有能力，合作仍在继续努力。这些研究增加了我们对PGB低聚物和钙三磷酸腺苷酶的作用机制及其在维持细胞内钙水平中的作用的理解。

This award will suport cooperative research between Prof. Thomas Devlin of Hahnemann University School of Medicine and Prof. Salvador Uribe of the National Autonomous University of Mexico (UNAM) in Mexico City. The investigators intend to study the effect of prostaglandin polymers on calcium ATPase in 2 systems: the human red blood cell plasma membrane and the sarcolemma of the rabbit heart. They will also study the effect of PG polymers on the metabolism of rat hepatocytes. The work on enzymes from human erithrocytes is to be performed at Hahnemann University while the work on rabbit heart sarcolemma and muscle sarcoplasmic reticulum will be carried out at UNAM. The investigators are capable and the collaboration continues an ongoing effort. These studies should add to our understanding of the mechanisms of action of the PGB oligomers and calcium ATPase and their role in maintaining intracellular calcium levels.