U.S.-Romania Research on Endothelial Transport of Glyco- albumin (Cell Biology)

这项由耶鲁大学的George Palade博士和布加勒斯特细胞生物学和病理学研究所的Nicolae Siminonescue博士合作的美国-罗马尼亚合作研究项目的主要目标是研究糖化蛋白在不同组织中通过连续内皮的运输机制。利用糖基化，糖尿病动物循环血浆中的一种非酶化学修饰，内皮细胞蛋白将被评估和表征。其目的是鉴定不同血管内皮质膜上的修饰蛋白。这些努力的结果应该有助于我们对正常和异常内皮功能的基本知识，而且这些发现可能会对未来处理与糖尿病相关的血管病变的研究产生影响。这个细胞生物学项目通过使美国和东欧的专家能够将互补的人才结合在一起，并在相互感兴趣和能力很强的领域汇集研究资源，实现了促进科学知识的计划目标。

The primary objective of this U. S.-Romania cooperative research project between Dr. George Palade of Yale University and Dr. Nicolae Siminonescue of the Institute for Cellular Biology and Pathology, Bucharest, is to study the mechanism of transport of glycated proteins across the continuous endothelium in various tissues. Using glycation, a non-enzymatic chemical modification in circulating blood plasma of diabetic animals, endothelia cell proteins will be evaluated and characterized. The intent is to identify modified proteins on the endothelial plasmalemma of different vessels. Results of these efforts should contribute to our basic knowledge of normal as well as abnormal endothelial functioning and findings may have bearing on future research addressing vascular lesions associated with diabetes. This project in cell biology fulfills the program objective of advancing scientific knowledge by enabling experts in the United States and Eastern Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence.