Reactive Intermediates and Reaction Mechanisms

这项赠款，由有机动力学计划， 化学，为杰罗姆博士的研究提供支持 耶鲁大学的贝尔森。研究的目的是 制备、分离和表征通常不稳定的 在化学反应中形成的中间体。化学和 反应性中间体的物理行为将是 与理论计算相关联。 要研究的主要中间体是双自由基， 贝尔森通过创新的合成路线制造。 他会隔离 他们使用的技术，如低温矩阵隔离 然后测量它们的光谱特性。 在温暖的时候，他可以 观察区域特异性二聚和环化 行为的双自由基和相关的结果与 理论这些研究增强了我们对以下问题的基本理解： 化学反应是如何发生的，应该是有用的沿着广泛的 化学合成的前沿

This grant, funded by the Organic Dynamics Program in Chemistry,provides support for the research of Dr. Jerome Berson at Yale University. The objective of the research is the preparation, isolation and characterization of often unstable intermediates formed in chemical reactions. The chemical and physical behaviour of the reactive intermediates will be correlated with theoretical calculations. The principal intermediates to be studied are biradicals, which Berson makes by innovative synthetic routes. He will isolate them using techniques such as low temperature matrix isolation and then measures their spectral properties. On warming he can observe the regiospecific dimerization and cyclization behaviour of the biradicals and correlate the results with theory. These studies enhance our fundamental understanding of how chemical reactions occur and should be useful along a broad front of chemical syntheses.