Equipment for an Undergraduate Biotechnology Laboratory Program

将建立生物化学项目的生物技术和计算机综合实验室，培训生物学、生物化学、化学等专业的重组DNA和单克隆抗体的生产和放大方法。因为这些方法已经成为许多科学领域的基础，作为本科生应该培养这些技能，用于必要的实习和自己的研究。在过去的七年里，这个系的生物化学专业的学生数量稳步增加；其中80%的人进入了医学院或研究生院。DNA电泳和印迹设备、倒置显微镜、超低温冷冻机、制备式离心机、发酵器和两个分光光度计可以进行DNA限制性图谱绘制、克隆和生产蛋白质和单抗。正在建立一个生物学计算中心，在那里，教师开发的软件允许学生在实验室经验之外，获得实验设计、数据收集和分析的经验。该项目的两个创新特征是1)将动手实验室与计算机模拟相结合，允许在短时间内以低成本进行现实的实验设计和数据分析的实际实验室体验，以及2)实验室为学生准备实习和研究的方式，在这种方式下，人们在整合多种方法的长期项目上进行合作。接受资助的机构正在将NSF的奖励与从非联邦来源获得的同等金额相匹配。

Integrated biotechnology and computer labs for the Biochemistry program will be set up to train biology, biochemistry, chemistry and other majors in recombinant DNA and monoclonal antibody production and scale-up methods. Because these methods have become basic to many areas of science, should develop these skills as undergraduates for use in required internships and their own research. The number of biochemistry majors in this department has steadily increased over the past seven years; 80% of them going on to medical or graduate schools. DNA electrophoresis and blotting equipment, an inverted microscope, an ultracold freezer, a preparative centrifuge, a fermenter and two spectrophotometers permit DNA restriction mapping, cloning, and the production of proteins and monoclonal antibodies. A Biology Computing Center is being established where faculty developed software allows students to gain experience with experimental design, data collection and analysis, in addition to their lab experience. Two innovative features of this project are 1) the integration of the hands-on labs with computer simulations, allowing for practical lab experience with realistic experimental design and data analysis in a short period at low cost, and 2) the way in which labs prepare students for internships and research where people cooperate on long- term projects that integrate several methods. The grantee institution is matching the NSF award with an equal sum obtained from non-Federal sources.