A Chemical Examination of Himalyan Aconitum Species, A Cooperative Project at the University of Georgia, Award inU.S. and Indian Currencies

描述：本项目支持印度科学家、印度奈尼塔尔Kumaon大学化学系的K.S. Khetwal博士参与乔治亚州雅典大学S. Pelletier博士管理的一个项目。本研究的目的是研究喜马拉雅地区某些含生物碱植物的生物碱成分，包括毛茛科植物乌头（Aconitum balfourii Stapf）、乌头（A. laeve Royle）和乌头（A. violaceum Jacq）。对这些植物的提取物进行生物活性筛选。这笔资金将使Khetwal博士能够前往雅典，并与Pelletier博士一起使用现代仪器（包括红外、GC-MS光谱、质子和碳-13核磁共振光谱）进行大约四个月的活性化合物结构测定。特定的同核-异核解耦、非共振技术、宽带解耦、NOE、弛豫实验和2d方法等技术将被用于进一步了解复杂结构。范围：该项目预计将增加对印度植物，特别是喜马拉雅地区植物的化学性质的了解，选择值得仔细研究的药理学上有趣的化合物，并更好地了解化学结构与生物活性之间的关系。这项工作将提高印度科学家开展有用的印美合作的能力。当他回到印度时，合作。

Description: This project supports participation of an Indian scientist, Dr. K.S. Khetwal of the Department of Chemistry, Kumaon University, Nainital, India, in a project managed by Dr. S. Pelletier at the University of Georgia, Athens, GA. The research objective is to investigate the alkaloid constituents of certain Himalayan alkaloid-bearing species, including Aconitum balfourii Stapf (Ranunculaceae), A. laeve Royle, and A. violaceum Jacq. The extracts of these species will be screened for their biological activities. The funds will enable Dr. Khetwal to travel to Athens and work with Dr. Pelletier for approximately four months on the structural determination of active compounds using modern instrumentation including infrared, GC-MS spectra, proton and carbon-13 NMR spectroscopy. Techniques such as specific homonuclear- heteronuclear decoupling, off-resonance techniques, broad band decoupling, NOE, relaxation experiments and 2D-methods will be utilized to provide further insight into the complex structures. Scope: The project is expected to increase understanding of the chemistry of Indian plants, especially those from the Himalayan region, to select pharmacologically interesting compounds that merit careful study, and to better understand the relationship between the chemical structure and the bioactivity. The work will enhance the capability of the Indian scientist for carrying out useful Indo-U.S. collaboration when he returns to India.