Alpha1-Adrenergic Receptor Subtypes in SmoothMuscle

这是一个研究血压调节过程的项目。正常情况下，大脑通过神经向动脉和静脉传递信息。这些神经的激活通过释放一种化学信使——去甲肾上腺素，导致血管收缩。血管肌肉细胞表面的去甲肾上腺素受体分子将被研究。明尼曼博士之前已经证明，有几种不同类型的这种受体，它们受到不同药物的不同影响。他现在将研究这些不同类型的受体导致血管收缩的分子机制。他特别感兴趣的是，这些受体是否通过不同的机制引起收缩，正如初步结果所表明的那样。识别这些不同的机制对于更好地理解血压是如何调节的，以及帮助找到有选择地控制血压的方法是很重要的。//

This is a project to examine some of the processes by which blood pressure is regulated. Normally, the brain sends messages to arteries and veins through nerves. Activation of these nerves causes the blood vessels to contract by releasing a chemical messenger, norepinephrine. The receptor molecules for norepinephrine which are on the surface of the muscle cells in the blood vessels will be studied. Dr. Minneman has previously shown that there are several different types of such receptors, which are affected differently by various drugs. He will now study the molecular mechanisms by which these different receptor types cause the blood vessels to contract. He is particularly interested in whether these receptors are acting through different mechanisms to cause contraction, as is suggested by preliminary results. Identification of these different mechanisms will be important in understanding more about how blood pressure is regulated, and in helping to identify ways to selectively control blood pressure. //