Modulation of Rhythmic Motor Activity in Peptide and Conventional Co-Transmitters in an Identified Neuron

这项研究的主要目的是了解一个人如何 调节神经元使用一种肽和一种常规的递质 来影响一个定义明确的神经网络的活动。 尽管许多系统中的神经网络活动已经被证明是 受到外源性肽的影响，很少有研究 详细描述了肽分泌神经元的作用。 的 要执行的项目集中在成对的调制 含催乳素神经元，两个同源肽能神经元 调节幽门网络的活动， 描述了一种神经元系统， 活动，并位于口胃神经系统的 螃蟹 该项目结合了生物化学和 电生理技术来解决一系列相关的 问题. 这项工作很重要，因为它使用了一个模型系统 来解决关于神经回路的重要细胞问题 与人类相似的基因

The main goal of this research is to understand how an individual modulatory neuron uses a peptide and a conventional transmitter to influence the activity of a well-defined neural network. Although neural network activity in many systems has been shown to be influenced by exogenously applied peptides, few studies have detailed the effects of peptide-secreting neurons. The projects to be performed focuses on the paired modulatory prolactin-containing neurons, two homologous peptidergic neurons that modulate the activity of the pyloric network, the best described neuronal ensemble which generates a rhythmic, patterned activity, and is located in the stomatogastric nervous system of the crab. This project combines biochemical and electrophysiological techniques to address a related series of questions. This work is important because it uses a model system to attack important cellular questions about neuronal circuits which are similar in man.