The Role of Insulin-like Growth Factors in Fetal Growth and Development

本研究的目的是开发一种体内系统， 用于研究母体血清的影响Insulin.like生长 IGF水平对胎鼠发育的影响。 识别 生长因子可能影响发育的几个方面 激发了人们对确定其影响范围的兴趣 和行动机制。 IGF.II被认为是一种调节剂， 胚胎发生和胎儿生长，拟议的研究寻求 最终确定这一含义的合理性。 的 实验方法将利用IGF.II分泌肿瘤， 提高孕妇IGF.II水平，并探讨其与妊娠结局的关系 胎盘水平升高。该因子的结合和通过， 以及胎儿生长的模式。 初步目标是 确定肿瘤系统的有效性， 胎盘和胎儿IGF II水平。 后续工作将在 致力于降低系统的解释复杂性， 这一水平将允许直接分析IGF.II对 胎儿 如果成功，该系统可能不容易生成数据 通过其他方法，并增加我们对 生长和发育的调节机制。 //

The objective of this research is to develop an in vivo system for study of the effects of maternal serum Insulin.like Growth Factor (IGF) levels on fetal rat development. The recognition that> growth factors may influence several aspects of development has excited interest in defining the true range of their effects and action mechanisms. IGF.II has been implicated as a regulator of embryogenis and fetal growth, and the proposed research seeks ultimately to determine the soundness of this implication. The experimental approach will utilize IGF.II secreting tumors to raise maternal IGF.II levels, and explore the relation of these elevated levels to placental.binding and passage of the factor, and to patterns of fetal growth. The initial objective is to determine the effectiveness of the tumor system for perturbing placental and fetal IGF.II levels. Subsequent efforts will be devoted to reducing the interpretive complexity of the system to a level that will permit direct analysis of IGF.II effects on the fetus. If successful, this system may generate data not easily available by other approaches, and increase our understanding of regulatory mechanisms of growth and development. //