The 1989 Mountain Lake Virginia Workshop and Symposium Addressing Transgenic Animals as Bioreactors for TherapeuticProteins

表达治疗性的转基因生产动物 它们乳汁中的蛋白质提供了一个潜在的重要来源 这可以增加血浆衍生蛋白。 组织（tissue） 培养）生产这些相同的蛋白质， 目前，基因工程哺乳动物细胞 进行翻译后修饰的能力。 这些修改可能是必要的适当 功能性和非免疫原性。 比如说， 蛋白质C的均匀修饰的生产（一个中心的 止血调节剂）的方法， 所达到的水平可能无法满足 目前预计每年需要100公斤蛋白C。 已经证实转基因动物可以被制造出来 在乳汁中生产人类蛋白质， as bioreactor生物反应器for that same相同purpose目的. 几个令人兴奋 在过去一年里，这一领域出现了新的发展， 用于啮齿动物和大型生产动物种属。 这 研讨会和讲习班是一系列两个- 提议召开会议，召集重要捐助者 （生物学家、生化工程师等）转基因 科学和牛奶加工。 核心和独特的目标 这个两部分的转基因动物研讨会是评估 这一快速发展的生物学领域 对生物化学工程和生产 蛋白质疗法

Transgenic production animals which express therapeutic proteins in their milk offer a potential significant source which could augment plasma-derived proteins. The (tissue culture) production of these same proteins using genetically engineered mammalian cells is currently limited in its ability to perform post-translational modifications. These modifications may be essential for proper functionally and non-immunogenicity. For example, uniformly modified production of Protein C (a central regulator of hemostasis) using mammalian cell culture is being achieved at levels which will probably not supply the currently projected l00 Kg per annum need for Protein C. It has been established that transgenic animals can be made to produce human proteins in their milk and therefore used as bioreactors for that same purpose. Several exciting developments in this area have occurred over the past year for both rodent and large production animal species. This symposium and workshop is the second of a series of two- proposed meetings to gather together important contributors (biologists, biochemical engineers, etc.) in transgenic science and milk processing. The central and unique goal of this two-part transgenic animal workshop is to assess the impact that this rapidly growing area of biology will have upon biochemical engineering and the production of protein therapeutics.