Renewal of Visual Cycle Components

这个项目将研究由脊椎动物光感受器合成的不同蛋白质是如何被包装并传递到它们的分泌部位的。众所周知，这些蛋白质中的每一种都以不同的方式被处理，但不知道这个复杂的过程是如何被调节的。研究的问题是蛋白质运输，这是细胞神经生物学中非常普遍的问题，而光感受器是研究这个问题的最简单的结构。因此，该项目将导致更好地了解神经细胞的正常和病理生物学。

This project will examine how different proteins which are synthesized by vertebrate photoreceptors are packaged and conveyed to their sites of secretion. It is known that each of these proteins is handled in a different manner, but it is not known how this complex process is regulated. The problem addressed, protein trafficking, is a very general one in cellular neurobiology and photoreceptors are the simplest structures in which the problem can be studied. Thus, the project will lead to a better understanding of the normal and pathological biology of nerve cells.