Spectroscopic Studies of Electronic Structure Analogues of Metalloprotein Active Sites

该奖项由无机，生物无机和有机化学 化学计划将支持爱德华一世博士的研究。 所罗门在生物无机化学。 金属络合物， 这些金属蛋白的活性位点的模型， 质体蓝素、天青蛋白、黄瓜蓝铜蛋白和 铁硫蛋白将通过广泛的 谱方法 研究将侧重于还原Cu（I）和HS Fe（II）中心，试图定义它们的电子 结构和电离的变化，从而探讨 这些蛋白质活性位点的氧化还原性质。 激发态光谱研究将扩展到两铁和 四个铁硫簇来定义与 二聚体相互作用和电子离域。 此外，光谱 一系列的蓝铜蛋白质将被比较， 质体蓝素，试图将结构变异 反应性。

This award from the Inorganic, Bioinorganic and Organometallic Chemistry Program will support the research of Dr. Edward I. Solomon in bioinorganic chemistry. Metal complexes which are models of the active sites of such metalloproteins as plastocyanin, the azurins, cucumber blue copper protein and iron sulfur protein will be investigated by a wide range of spectral methods. Studies will focus on reduced Cu(I) and HS Fe(II) centers, attempting to define their electronic structures and the change on ionization, thus probing the oxidation-reduction properties of such protein active sites. Excited state spectral studies will extend to two-iron and four-iron sulfur clusters to define features associated with dimer interactions and electron delocalization. Also, spectra of a series of Blue Copper proteins will be compared to plastocyanin in an attempt to correlate structural variations with reactivity.