Cycles of Domoic Acid Producers in Culture and Coastal Waters

Demoic acid是一种强有力的神经毒素，已从 硅藻物种刺菱形藻（浮游植物）在某些 环境条件，特别是二氧化硅耗尽。当 该物种被贝类摄取，它被浓缩， 对任何食用它们的人来说都是一种神经危害。 这一现象在2000年引起了公众的注意。 加拿大爱德华王子岛发生的一起中毒事件， 吃贻贝。最近将demoic酸与贝类联系起来 中毒（在过去两年中）是特别令人关注的 由于硅藻刺菱形藻Nitzschia pungens var.多系列是一个 在我们的许多沿海沃茨中到处都是物种。博士 弗里克塞尔成功地克隆了这种生物体， 以及来自加尔维斯顿湾的。因为 对这种毒素的调节几乎一无所知 在这个物种的生产，特别是关于生活周期 阶段，至关重要的是，demoic酸生产的周期 被解决。

Demoic acid, a potent neurotoxin, has been isolated from the diatom species Nitzschia pungens (phytoplankton) under certain environmental conditions, particularly silica depletion. When this species is ingested by shellfish, it is concentrated and represents a neurological hazard to any human who consumes them. This phenomenon was brought to the awareness of the public during an episode of poisonings in Prince Edward Island, Canada after eating mussels. This recent linkage of demoic acid with shellfish poisoning ( within the last two years) is of particular concern since the diatom Nitzschia pungens var. multiseries is a ubiquitous species thriving in many of our coastal waters. Dr. Fryxel has succeded in cloning the organism both from the Canadian bloom as well as from Galveston Bay. Because there is virtually nothing known about the regulation of the toxin production in this species especially with regard to life cycle stages, it is critical that the cycles of demoic acid production be worked out.