Minority Research Initiation Planning Grant

提出的研究目的是继续评估高能、高质量离子及其对傅里叶变换离子回旋共振（FT-ICR）质谱分析分辨率的影响。在申请资助期间，研究者将准备一份竞争性研究计划，其中将包括拟议文本中所述的实验室实验。也就是说，他将批判性地评估计算机模拟所揭示的离子物理，以设计他的实验室实验。他认为这种方法在高质量FT-ICR的发展中是必不可少的。他认为FT-ICR可以在生物分析质谱中发挥重要作用，从需要超高灵敏度的应用到处理结构（例如氨基酸序列）和结构/功能关系的更复杂领域。

The objective of the proposed research is the continued evaluation of high energy, high mass ions and their effect on resolution for Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. During the requested funding period, the investigator will prepare a competitive research proposal that will incorporate laboratory experiments along the lines illustrated in the proposed text. That is, he will critically evaluate the ion physics as revealed by the computer simulations to design his laboratory experiments. He considers that such an approach is essential in the development of high mass FT-ICR. He suggests that FT-ICR can play a major role in bioanalytical mass spectrometry, ranging from applications that require ultrahigh sensitivity to more complex areas dealing with structure (e.g. amino acid sequence) and structure/function relationships.