Functional Interactions Between Neuronal 5-HT and Glial S-100 Beta

发育神经生物学的一个中心问题是 细胞间相互作用调节神经元分化。 星形胶质细胞分泌影响神经元 分化，包括S-100 β，一个影响 肾上腺素能神经元。 反过来，S-100 β的分泌从 星形胶质细胞受肾上腺素能神经元的激活调节。 这些细胞相互作用的机制将是 在分子水平上进行研究， S-100 β的转录、翻译和释放。 在 此外，类固醇激素的调节作用，特别是 糖皮质激素，在这些过程中将被研究。 的pi 将在冷泉港进行这些研究， 一年的休假，他将在那里接受分子和 丹尼尔·马沙克博士实验室的蛋白质技术。

A central issue in developmental neurobiology is the role of cell-cell interactions in regulating neuronal differentiation. Astrocytes secrete factors that influence neuronal differentiation, including S-100 beta, a factor that affects serotonergic neurons. In turn, the secretion of S-100 beta from astrocytes is regulated by activation of serotonergic neurons. The mechanisms of these cellular interactions will be investigated at the molecular level by studying the transcription, translation and release of S-100 beta. In addition, the regulatory role of steroid hormones, specifically the glucocorticoids, in these processes will be studied. The PI will undertake these studies at Cold Spring Harbor during a one year Sabbatical leave where he will be trained in molecular and protein techniques in the laboratory of Dr. Daniel Marshak.