Synthesis and Study of Some Theoretically Interesting Molecules

有了这个奖项，合成有机计划将支持华盛顿大学化学系的Weston T.Borden博士的研究。这项拟议的研究包括实验化学和计算化学的综合结合，有助于准备和理解高度应变的有机分子的化学。在工作的实验部分，将进行一系列金字塔化烯烃的制备和性质的研究。这些化合物将使用基质技术进行分离，并将作为其他有趣的应变分子和一系列铂配合物的前体。在计算工作中，除了其他项目外，还将进行从头计算，以测试取代基对立方阳离子、高铜-1(9)-烯和COPE重排的影响。还将进行计算，以指导和解释锥化烯烃铂络合物的实验研究。

With this award, the Synthetic Organic Program will support the research of Dr. Weston T. Borden of the Department of Chemistry at the University of Washington. The proposed research includes an integrated combination of experimental and computational chemistry leading to the preparation and understanding of the chemistry of highly strained organic molecules. In the experimental portion of the work, the preparation and study of the properties of a series of pyramidalized alkenes will be undertaken. The compounds will be isolated using matrix techniques and will serve as precursors to other interesting strained molecules and to a series of Pt complexes. In the computational work, among other projects, ab initio calculations will be carried out in order to test the effect of substituents on cubyl cation, homocub-1(9)-ene, and the Cope rearrangement. Calculations will also be carried out that will serve to guide and interpret experimental studies of Pt complexes of pyramidalized alkenes.