Post-Translational Regulation of N-Cadherin During Neural Development

钙依赖的细胞黏附分子N-钙粘附素的表观遗传调控在细胞黏附中的作用将在鸡的神经视网膜中进行研究。将进行生化研究，以描述N-钙粘蛋白通过磷酸化和硫酸盐化的翻译后修饰，并将确定这些翻译后修饰与N-钙粘蛋白功能的关系。更广泛地说，这些研究将确定细胞间相互作用的机制，这些机制对神经元特异性的发展非常重要。

The role of epigenetic regulation of the calcium dependent cell adhesion molecule, N-cadherin, in cell adhesion will be studied in the chick neural retina. Biochemical studies will be performed to describe the post-translational modification of N- cadherin by phosphorylation and sulfation and the relationship of these post-translational modifications to N-cadherin function will be determined. More generally, these studies will define mechanisms involved in cell-cell interactions that are important to the development of neuronal specificity.