Structural Recognition in Complexation of Organic Compounds

研究有机主客体间配合物的化学性质。研究的重点是将客人禁锢在刚性中空的寄主中，寄主要么没有孔（空心），要么在壳上有孔（半空心）。在分子量约为80-120的范围内，将测量脂肪族和芳香族的半复合物收缩结合的自由能。络合和解合的速率将与半脑丛中访客和入口的相对大小相关。将比较在溶解的半复合物的内相中进行的反应的速率和产物，以及在不含宿主的相同溶剂中进行的反应。客人将被设计、准备和研究，其中只有一部分可以被监禁，其余的太大而无法通过主人的入口。一根小分子绳将这两部分连接起来。其他客人将被研究，其中一部分将包含在一个半容器中，另一部分将包含在另一个半容器中。产物将是由短分子链连接的两个半复合物。将设计和合成新的癌症和半癌症家族。有机合成计划正在资助这项诺贝尔奖研究的更新。它将继续发展囚禁在大分子内部的小分子化学。这项工作有可能导致非常独特的新反应模式。

The chemical character of complexes between organic hosts and guests will be studied. The research will focus on the incarceration of guests in rigidly hollow hosts either without holes (carcerands) or with holes (hemicarcerands) in their shells. The free energies of constrictive binding by hemicarceplexes will be measured for both aliphatic and aromatic guests in the molecular weight range of about 80-120. The rates of complexation and decomplexation will be correlated with the relative sizes of the guests and portals in hemicarceplexes. Comparisons will be made between the rates and products of reactions run in the interior phases of dissolved demicarceplexes, and those run in the same solvents free of the hosts. Guests will be designed, prepared, and studied, only a part of which can be incarcerated, the rest being too large to pass through the portals of the hosts. A small molecular tether will connect the two parts. Other guests will be studied, one part of which will be contained in one hemicarcerand and a second part in a second hemicarcerand. The product will be two hemicarceplexes connected by a short molecular tether. New families of carcerands and hemicarcerands will be designed and synthesized. The Organic Synthesis Program is funding the renewal of this Nobel Prize research. It will continue its development of the chemistry of small molecules imprisoned inside larger molecules. The work has the potential to lead to very unique new patterns of reactivity.