Photodynamics of Metalloporphyrins

格林鲍姆博士建议研究一组用作血红素加氧酶抑制剂的合成金属卟啉的环境特异性光动力活性。其中一些卟啉在有氧环境中吸收光导致单线态氧的产生，这可能导致目标生物分子的不可逆修饰。特定化合物的光反应性取决于中心金属原子、环取代基和卟啉所处的环境。通过使用各种生化和光谱技术，将研究静电相互作用在卟啉-卟啉、卟啉-蛋白和卟啉-膜结合中的重要性，以及卟啉介导的对这些模型系统中各种目标的损伤的具体机制。

Dr. Greenbaum proposes to study the environment-specific photodynamic activity of a group of synthetic metalloporphyrins used as heme oxygenase inhibitors. Absorption of light by some of these porphyrins in aerobic environments results in generation of singlet oxygen, which may cause irreversible modification of target biological molecules. The photoreacitivity of a particular compound depends upon the central metal atom, ring substituents, and the environment in which the porphyrin is localized. By use of various biochemical and spectroscopic techniques, the importance of electrostatic interactions in porphyrin-porphyrin, porphyrin-protein, and porphyrin-membrane associations and specific mechanisms of porphyrin-mediated damage to the various targets in these model systems will be studied.