Novel Platinum Thiazole Complexes

该项目涉及的合成和表征的 噻唑衍生物的铂络合物和随后的 它们与核酸的结合及其 选民。 这将是本科生研究的一部分， 特伦顿州立大学的一个项目。 详细审查 计划通过X射线晶体学对复合物进行分析。 额外 工作将包括对它们的结合模式的详细分析 以阐明与DNA相互作用的机制。 %%% 研究规划赠款使以前没有 独立的联邦研究支持， 研究提案。 该项目涉及综合和 铂金属有机化合物的表征 与DNA结合

The project involves the synthesis and characterization of the platinum complexes of thiazole derivatives and subsequent studies of their binding to nucleic acids and their constituents. This will be part of an undergraduate research program at Trenton State College. A detailed examination of the complexes by x-ray crystallography is planned. Additional work will include a detailed analysis of their binding modes in order to elucidate the mechanism of interaction with DNA. %%% Research Planning Grants enable women who have not had prior independent Federal research support to develop a competitive research proposal. This project involves the synthesis and characterization of platinum organometallic compounds and their bonding to DNA.