Quantitative Morphology Tutorials and Databases for Biology

9121456 Bolender该项目将利用信息技术为生命科学中的定量形态学（QM）创建一个新的基础设施。它包括：(1)教程、数据库和查询工具的软件；(2)22种动物器官的公开数据文件；(3)电子提交数据的设施。该项目的意义在于，它使质量管理的方法和数据易于社区获得，并对结构化信息进行分层组织，并提供新的研究工具。新的教程通过使用详细的描述、工作示例、计算工作界面、模拟和工具包，提供QM方面的培训，包括形态测量学、立体学和重建。它提供：(1)希望使用QM数据库的生物学家和计算机科学家的背景材料；(2)对在实验室中使用这些方法感兴趣的研究人员的最先进的工具。数据库包括教程、数据输入表格、发布的数据和查询工具。报告允许最终用户标准化、回收和创建新数据。QM数据的一种新的表示，称为结构表型，简化了在文献中搜索结构类比和概括的任务。该项目积极支持QM的使用，并为Biomatrix提供了一个结构组件。此外，调查人员将开始将他的工作移植到工作站环境。该提案得到了教育和人力资源理事会先进技术应用计划以及计算生物学活动计划的联合支持。***定量形态学教程和生物学数据库

9121456 Bolender This project will create, using information technologies, a new infrastructure for quantitative morphology (QM) in the life sciences. It includes: (1) software for tutorials, databases, and query tools, (2) files of published data for 22 animal organs, and (3) facilities for electronic submission of data. The significance of the project is that it makes the methods and data of QM readily available to the community, organizes structural information hierarchically, and provides new research tools. The new tutorial supplies training in QM, which include morphometry, stereology, and reconstruction, through use of detailed descriptions, worked examples, calculation workscreens, simulations, and toolkits. It provides: (1) background material for biologists and computer scientists wishing to use the QM databases and (2) state-of-the-art tools for researchers interested in using these methods in the laboratory. The databases include a tutorial, data entry forms, published data and query tools. Reports allow end-users to standardize, recycle, and create new data. A new representation of QM data, called the structural phenotype, simplifies the task of searching for structural analogies and generalizations across the literature. The project actively supports the use of QM and contributes a structural component to Biomatrix. Furthermore the investigator will begin to port his work to the workstation environment. This proposal is being jointly supported by the Applications of Advanced Technology program in the Directorate for Education and Human Resources as well as the Computational Biology Activities program. *** Quantitative Morphology Tutorials and Databases for Biology