Antibody Catalysis

本研究的重点是产生和鉴定抗体，这些抗体将催化Oxy-Cope重排、酰胺水解和大内酯化。这项工作以半抗原设计为中心，并依赖于正源博士在合成有机化学方面的经验。有了这个更新奖，合成有机项目正在支持麻省理工学院化学系的sato Masamune博士的研究。Masamune教授将把他的工作重点放在能够产生抗体的半抗原分子的合成上。这些抗体反过来又是许多重要的合成有机反应的催化剂。

The focus of this research is the generation and characterization of antibodies which will catalyze the Oxy-Cope rearrangement, amide hydrolysis and macrolactonization. The work centers on hapten design and relies on Dr. Masamune's experience in synthetic organic chemistry. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Saturo Masamune of the Department of Chemistry of the Massachusetts Institute of Technology. Professor Masamune will focus his work on the synthesis of molecules called haptens that are capable of raising antibodies. The antibodies, in turn, are catalysts for a number of important synthetic organic reactions.