Cation Radicals in Solution

计划在阳离子自由基催化的基础上发展新的和合成有用的反应。通过对这些新反应的选择性和机理的深入研究，探讨了这些新反应的优点和性质。对催化反应中阳离子自由基中间体极敏感的机理探针已经设计出来，并将进一步定量和完善。这些探针将允许这些催化机制的明确检测，一般来说，这些是有效的。这个强大的，新的催化原理的全部范围可以这样定义。参与催化机制在生物和酶模型催化环氧化将使用这些探针进行检查。自由基阳离子催化在其他生物氧化反应中的作用及其与氧化反应的关系也将被研究。有了这笔奖金，有机合成项目将继续支持德克萨斯大学内森·l·鲍尔德博士的研究。该研究探索了阳离子自由基化学的新分支和应用。它将产生有利于生物化学和医学以及化学工业研究的新方法。

The development of new and synthetically useful reactions based upon cation radical catalysis is planned. The advantages and attributes of these new reactions will be investigated by means of thorough study of their selectivity profiles and mechanisms. Extremely sensitive mechanistic probes for the cation radical intermediates involved in catalyzed reactions have been designed and will be further quantitated and perfected. These probes will permit the definitive detection of these catalytic mechanisms, in general, where these are operative. The full scope of this powerful, new catalytic principle can thus be defined. The involvement of a catalytic mechanism in biological and enzyme model catalyzed epoxidation will be examined using these probes. The involvement of radical cation catalysis in, or its relationship to other biological oxidation reactions will also be examined. %%% With this award, the Organic Synthesis Program will continue to support the research of Dr. Nathan L. Bauld at the University of Texas. The research explores new ramifications and applications of the chemistry of cation radicals. It will generate new methodology that should benefit research in biochemistry and medicine as well as in the chemical industry.