Research on Doppler Three-Dimensional Vector and Capillary Flow Measurement

这笔赠款将用于研究超声多普勒技术以评估血液。速度和检测与血流相关的情况。通过操纵超声换能器的孔径，将产生线型回波频谱，从该频谱中三维血流速度向量，而不是仅仅估计沿声束轴线和垂直于声束轴线的速度分量。毛细血管血流量和灌注量也将通过使用超声造影剂进行测量，可以注射到血液中。这些造影剂在入射辐射的二次谐波处的回声比组织强得多，因此毛细血管回声与周围组织回声的比率将增强。这项研究很重要，因为它可能导致超声波技术的进步，包括电流互感器性能的改进和具有一定工作特性的互感器的设计。这项研究还可以在一些传统系统无效的地方进行流量测量。对比研究应该能够更有效地显示灌注度。这些后一项研究也将使第一次使用超声波测量毛细血管流量成为可能。

This grant will fund the investigation of ultrasound Doppler techniques to estimate blood velocity and detect blood flow related conditions. By manipulating the aperture of an ultrasound transducer, a line type echo spectra will be produced from which the 3-D blood velocity vector, rather than merely the velocity components along and normal to the sound beam axis, will be estimated. Capillary blood flow and perfusion also will be measured through the use of ultrasound contrast materials which can be injected into the blood. These contrast agents have a much stronger echo at the second harmonic of the incident radiation than does tissue and therefore the ratio of the capillary blood echo to that of the surrounding tissue will be enhanced. This research is important since it could lead to advances in ultrasound technology, including the improvement of the performance of current transducers and the design of transducers with certain operating features. The research also could enable flow measurements to be made in some locations where conventional systems are ineffective. The contrast studies should enable more effective visualization of the degree of perfusion. These latter studies also should enable the first measurement of capillary flow to be made using ultrasound.