Elucidating the Determinants and Mechanisms of Tau Liquid - Liquid Phase Separation In Situ at Multiple Length Scales from µm to Å: Exploring the Role of Membraneless Compartments in Alzheimer's Disease
Elucidating the Determinants and Mechanisms of Tau Liquid - Liquid Phase Separation In Situ at Multiple Length Scales from µm to Å: Exploring the Role of Membraneless Compartments in Alzheimer's Disease
批准号:
440931
负责人:
Ahmed Rashik
金额:
$10.93万
依托单位国家:
加拿大
项目类别:
Fellowship Programs
财政年份:
2020
资助国家:
加拿大
项目状态:
已结题
起止时间:
2020-12-01 至 2023-12-01
中文摘要
大脑中由tau蛋白组成的病理性聚集体的积聚是阿尔茨海默病(AD)的临床特征。阿尔茨海默病的进展与tau聚集体即神经原纤维缠结(NFTs)的扩散密切相关
英文摘要
The build-up of pathological aggregates in the brain comprised of the tau protein is a clinical hallmark of Alzheimer's disease (AD). The progression of AD is closely associated with the spreading of tau aggregates i.e. neurofibrillary tangles (NFTs), thr
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会议论文
Catechins as Adjuvants in the Treatment of Alzheimer's Disease: Enhancing the Response of Microglia to Amyloid Beta
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批准号:383278
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项目类别:Studentship Programs
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资助金额:$7.65万
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财政年份:2017
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负责人:Ahmed Rashik
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依托单位:
Probing the Interactions between (-) Epigallo-3-catechin Gallate & Amyloid Beta Assemblies in Alzheimer's Disease
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批准号:367025
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项目类别:Studentship Programs
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资助金额:$1.27万
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财政年份:2016
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负责人:Ahmed Rashik
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依托单位:
海外基金