Catalytic Activation and Oxidation of C-H Bonds by Soluble Platinum Compounds

这个无机、生物无机和有机金属项目的奖项为宾夕法尼亚州立大学化学系的Ayusman Sen博士关于碳氢键氧化的研究提供了持续的支持。Sen发现未激活的C-H键被Pt（II）络合物选择性地攻击，而Pt(0)则激活了与氧或氮的C-H键。他建议研究该体系的机理细节，以表征C-H活化步骤，中间有机金属的结构和反应性，可以使该体系具有催化作用的助氧化剂的类型，以及选择性的来源。多种有机化合物，如烷烃、醚和醇，在温和条件下可在水溶液中被铂（II）氧化。这个潜在的非常有用的有机合成反应还没有被很好地理解。森将对反应过程进行详细的研究，以便发现如何在包含许多碳氢键的系统中使其与特定的碳氢键反应。研究结果对化工行业的大规模生产和特种产品的生产具有实用价值。

This award in the Inorganic, Bioinorganic, and Organometallic Program provides continued support for research by Dr. Ayusman Sen of the Chemistry Department, Pennsylvania State University, concerning the oxidation of carbon-hydrogen bonds. Sen has found that unactivated C-H bonds are attacked selectively by Pt(II) complexes, whereas Pt(0) activates C-H bonds alpha to oxygen or nitrogen. He proposes to study the mechanistic details of the system in order to characterize the C-H activation step, the structure and reactivity of the intermediate organometallic species, the types of cooxidants that could make the system catalytic, and the origins of the selectivity. %%% A variety of organic compounds, such as alkanes, ethers, and alcohols, can be oxidized in aqueous solution under mild conditions by platinum (II). This potentially very useful reaction for organic synthesis is not well understood. Sen will carry out a detailed investigation of how the reaction proceeds in order to discover how it can be made to react with specific carbon-hydrogen bonds in a system that contains many carbon-hydrogen bonds. The results have utility in the chemical manufacturing industry, both for the production of large scale and specialty products.