Computational Investigations of Pulmonary Airway Clearance

本研究将探讨 液体阻塞物的清除 从肺部气道通过 使用数学模型。 这 将通过调查 气道内壁之间的关系- 流体特性和气道 结构特性 压力和应力 随着肺部清除率的增加， 障碍物 该研究还将 确定不溶性表面活性剂 外加压力影响墙 清除期间的应力 阻塞的呼吸道 最后 该项目将评估 表面活性剂从 体相到表面相 在障碍物影响范围内 所施加的压力以及由此产生的 间隙期间的壁应力 呼吸道阻塞 这项研究可能会改善 清除肺气道的方法 障碍物 创新 本研究所采用的方法也 可能有助于调查 界面现象和输运 其他领域的进程。

This study will investigate the clearance of liquid obstructions from pulmonary airways through the use of mathematical models. This will be done by investigating the relationship between airway lining- fluid characteristics and airway structural properties on the pressures and stresses associated with the clearance of pulmonary obstructions. The study also will determine how insoluble surfactant and applied pressure influence wall stresses during the clearance of obstructed airways. Finally, the project will evaluate how the transport of surfactant from the bulk-phase to the surface-phase within the obstruction influence the applied pressures and resulting wall stresses during the clearance of obstructed airways. The research may lead to improve methods to clear pulmonary airway obstructions. The innovative methods applied in this study also may be useful in investigating interfacial phenomena and transport processes in other areas.