Synthesis of Cyclopeptic Alkaloids

这项工作的重点是合成路线的开发 以生产植物大环缩肽为目标， 起源 具体目标是优化合成的数量 14元环肽生物碱， β-羟基-α-氨基酸。 目标是毛里亭A， sanjoinine A、全盖肾碱和膜荚壳碱。 结构性 这些自然界中的构象和金属络合问题 产品也将得到解决。 %%% 有了这个奖项，合成有机计划正在支持 Madeleine M.博士的研究。司法部的朱利 宾夕法尼亚大学化学系。 朱利教授 她的工作将集中在合成一类天然的 产品称为环肽生物碱。 的困难 从天然来源中大量分离化合物， 使工作变得令人向往。

The focus of this work is the development of synthetic routes towards the production of macrocyclic depsipeptides of plant origin. Specific goals are the optimized syntheses of a number of 14-membered cyclopeptide alkaloids containing beta-hydroxy-alpha-amino acids. The targets are mauritine A,, sanjoinine A, integerrenine and hymenocardine. The structural issues of conformation and metal-complexation in these natural products will be addressed also. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Madeleine M. Joullie of the Department of Chemistry at the University of Pennsylvania. Professor Joullie will focus her work on the synthesis of a class of natural products known as cyclopeptide alkaloids. The difficulty in isolating the compounds in quantity, from natural sources, makes the work desirable.