Renewal of Visual Cycle Components

该提案侧重于细胞内运输，“蛋白质 神经元中的“贩运”。 高度极化的神经元 细胞，必须合成，易位，包装大量的 细胞内、细胞外和膜蛋白， 保持其正常的结构和功能。 感光器 一个高度极化的神经元的例子， 将膜蛋白转移到外节蛋白， 光感受器间隙和突触末梢。 并不完全 清楚神经元如何处理这么多蛋白质的加工。 Carter-Dawson博士提议使用感光细胞作为模型 检查细胞外基质成分的加工， 膜糖蛋白 除了提供关于以下方面的信息外， “蛋白质运输”在神经元，这项研究还将提供 为实现长期目标提供更多信息 光感受器间基质和视觉周期成分 正常、发育和成熟的视网膜。

This proposal focuses on intracellular transport, "protein trafficking," in neurons. Neurons, which are highly polarized cells, must synthesize, translocate, and package numerous intracellular, extracellular, and membrane proteins in order to maintain their normal structure and function. The photoreceptor is an example of a highly polarized neuron which must produce and transfer membrane proteins to the outer segment proteins to the interphotoreceptor space and synaptic terminal. It is not entirely clear how neurons handle the processing of so many proteins. Dr. Carter-Dawson proposes to use the photoreceptor cell as a model to examine the processing of extracellular matrix constituents and membrane glycoproteins. In addition to providing information on "protein trafficking" in neurons, this study will also provide additional information towards the long-term goal of characterizing the interphotoreceptor matrix and visual cycle components in normal, developing, and mature retinas.