Minority Postdoctoral Research Fellowship

烟碱乙酰胆碱受体与外周膜蛋白43K蛋白之间的关系已被描述。这些受体在突触后膜中的聚集是突触形成的早期和关键步骤。在周围神经系统的神经肌肉突触中，已知43K蛋白在突触后位置的受体聚集和锚定中起主要作用。申请人将试图阐明这些受体在中枢神经系统突触发育早期聚集的机制，并描述43K蛋白或同源物的作用。这项工作将在北卡罗来纳大学医学院Stanley Froehner博士的实验室进行。* * *

9308054 Melton A relationship between nicotinic acetylcholine receptors and a peripheral membrane protein designated the 43K protein has been described. Aggregation of these receptors in the postsynaptic membrane is an early and crucial step in synapse formation. In neuromuscular synapses in the peripheral nervous system, the 43K protein is known to play a major role in clustering and anchoring the receptors at the postsynaptic site. The applicant will attempt to elucidate the mechanism(s) by which these receptors aggregate early in the development of synapses in the central nervous system, and characterize the role of the 43K protein, or homologue. This work will be conducted in the laboratory of Dr. Stanley Froehner at the University of North Carolina School of Medicine.. ***